Brain Tumors Research Today is a free monthly online journal that collates and summarizes the latest research about Brain Tumors, including details on symptoms, benign and malignant tumors, gliomas, screening, treatment. | ||||||
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Mediastinal radiotherapy after multidrug chemotherapy and prophylactic cranial irradiation in patients with SCLC--treatment results after long-term follow-up and literature overview.Herrmann MK, Bloch E, Overbeck T, Koerber W, Wolff HA, Hille A, Vorwerk H, Hess CF, Muller M, Christiansen H, Pradier O Department of Radiotherapy, University Hospital Goettingen, Robert-Koch-Str 40, 37075 Goettingen, Germany. Published 28 March 2011 in Cancer Radiother, 15(2): 81-8. Articles on Brain Tumors published 17 March 2011: Chemotherapy wafers for high grade glioma. Cochrane Database Syst Rev, 3: CD007294. Chemotherapy wafers for high grade glioma. Cochrane Database Syst Rev, 3: CD007294. Inconsistent immunohistochemical expression patterns of four different CD133 antibody clones in glioblastoma. J Histochem Cytochem, 59(4): 391-407. The putative tumor stem cell marker CD133 is the marker of choice for identifying brain tumor stem cells in gliomas, but the use of different CD133 antibody clones possibly recognizing different CD133 splice variants with epitopes of different glycosylation status confuses the field. The aim was to investigate if current inconsistent CD133 observations could be a result of using different CD133 antibodies for immunohistochemical identification of CD133. Ten glioblastomas were ... [Abstract] [Full-text] Supratentorial primitive neuroectodermal tumors of the central nervous system in adults: molecular and histopathologic analysis of 12 cases. Am J Surg Pathol, 35(4): 573-82. Advances in understanding the molecular basis of primitive neuroectodermal tumors of the central nervous system (CNS-PNET) biology are critical to improve patient outcome. Recently, new data on their molecular features have been reported, suggesting that supratentorial PNET (s-PNET) in adult patients may represent a specific tumor entity among CNS-PNETs. In this study, we analyzed the clinicopathologic and molecular features of 12 cases of s-PNET in adult patients. The follow-up analysis showed ... [Abstract] [Full-text] Articles on Brain Tumors published 16 March 2011: Predominant influence of MGMT methylation in non-resectable glioblastoma after radiotherapy plus temozolomide. J Neurol Neurosurg Psychiatry, 82(4): 441-6. Articles on Brain Tumors published 9 March 2011: 5'-AMP-activated protein kinase activity is elevated early during primary brain tumor development in the rat. Int J Cancer, 128(9): 2230-9. We found that adenosine 5'-monophosphate-activated protein kinase (AMPK), which is considered the "fuel sensor" of mammalian cells because it directly responds to the depletion of the fuel molecule ATP, is strongly activated by tumor-like hypoxia and glucose deprivation. We also observed abundant AMPK activity in tumor cells in vivo, using subcutaneous tumor xenografts prepared from cells transformed with oncogenic H-Ras. Such rapidly growing transplants of tumor cells, however, ... [Abstract] [Full-text] Articles on Brain Tumors published 28 February 2011: Radiotherapy in small-cell lung cancer: lessons learned and future directions. Int J Radiat Oncol Biol Phys, 79(4): 998-1003. Although chemotherapy is an essential component in the treatment of small-cell lung cancer, improvements in survival in the past two decades have been mainly achieved by the appropriate application of radiotherapy. The aim of the present study was to review the key developments in thoracic radiotherapy and prophylactic cranial radiotherapy and to discuss the rationale behind key ongoing studies in small-cell lung cancer. [Abstract] [Full-text] Inter- and intrafractional positional uncertainties in pediatric radiotherapy patients with brain and head and neck tumors. Int J Radiat Oncol Biol Phys, 79(4): 1266-74. © 2004-2011 Brain Tumors Research Today. All Rights Reserved. |
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