Brain Tumors Research Today is a free monthly online journal that collates and summarizes the latest research about Brain Tumors, including details on symptoms, benign and malignant tumors, gliomas, screening, treatment.

Medulloblastoma: developmental mechanisms out of control.

Marino S

Institute of Clinical Pathology, University Hospital, Schmelzbergstrasse 12, 8091 Zürich, Switzerland. silvia.marino@usz.ch

Medulloblastoma, which is a highly aggressive central nervous system neoplasm, represents an intriguing example of how deregulated developmental mechanisms can lead to tumour development. Recent advances in the understanding of the role of Sonic Hedgehog, Wnt and Notch signalling pathways in the development of the cerebellum have shed new light on medulloblastoma pathogenesis.

Published 14 January 2005 in Trends Mol Med, 11(1): 17-22.
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