Brain Tumors Research Today is a free monthly online journal that collates and summarizes the latest research about Brain Tumors, including details on symptoms, benign and malignant tumors, gliomas, screening, treatment.

Rosai-Dorfman disease presenting with widespread intracranial and spinal cord involvement.

Kidd DP, Revesz T, Miller NR

Department of Clinical Neurosciences, Royal Free Hospital, London, UK. d.kidd@medsch.ucl.ac.uk

Rosai-Dorfman disease is associated with a histiocytic infiltration of lymphoid tissue, but may also involve the orbit, nasopharynx, respiratory pathways, gastrointestinal tract, endocrine glands (particularly the thyroid), bone, and skin. Neurologic manifestations are rare, occurring in 4% of one series, and the diagnosis is often not made until pathology is available. Using data from two cases, we present the clinical manifestations, pathology, and treatment, and review the literature regarding the ocular and neurologic manifestations. Finally, we discuss the optimum management of this disorder.

Published 14 November 2006 in Neurology, 67(9): 1551-5.
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