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Psammomatous choroid plexus papilloma: three cases with atypical characteristics.

Tena-Suck ML, López-Gómez M, Salinas-Lara C, Arce-Arellano RI, Biol AS, Renbao-Bojorquez D

Departament of Neuropathology, National Institute of Neurology and Neurosurgery, Mexico City, Mexico 14269. tenasuck@yahoo.com

BACKGROUND: Intravertricular papillary neoplasms are derived from choroid plexus epithelium. Although choroid plexus tumors account for 0.4% to 0.6% of all brain tumors, they represent 2% to 4%. Approximately 80% of choroid plexus carcinomas arise in children. CASES DESCRIPTION: We describe 3 cases of choroid plexus papilloma (CPP) with profuse psammomatous bodies and calcifications that have lost their normal papillary architecture. Immunohistochemistry was positive for glial fibrillary acidic protein in 2 cases, and proliferating cellular nuclear antigen index was higher compared with regular CPPs. All 3 patients were female and were 12, 40, and 48 years old, respectively. CONCLUSION: We describe psammomatous CPPs and suggest a difference from CPPs because of the more aggressive clinical course, and higher nuclear proliferation index (proliferating cellular nuclear antigen) than the CPPs that lack psammoma bodies.

Published 24 May 2006 in Surg Neurol, 65(6): 604-10.
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